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KMID : 0376419860100010067
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Chonbuk University Medical Journal
1986 Volume.10 No. 1 p.67 ~ p.72
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Influence of Chronic Morphine Administration to the Action of Acetylcholine in Isolated Rat Vas Deferens
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Abstract
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Effect of acetylcholine (ACh) on contractile force of isolated vas deferens in control and chronic morphine-treated rat was investigated in this experiment. Preparations were applied with field stimulation(O. 1 Hz. 10 msec of duration and 100 volts).
1 . ED50 and maximal´ response of control preparation to ACh were 8.3 ± 0.6 PM and 1736.8± 112.7mg/10mg wet weight respectively.
2 . In chronic morphine-treated preparation, ED5o of ACh(4.5±0.4pM) was significantly
reduced, whereas maximal response (1946.8±132.2mg/lOmg wet weight) was slightly increased. 3 . In these preparations, dose of ACh in the presence of atropine´was highly increased. 4. pA2 value(affinity index of antagonist) of the chronic morphine-treated group was higher
than that of control group.
From the above results, it is suggested that development of acetylcholine supersensitivity by chronic morph´ae treatment is due to increase of muscarinic receptor affinity and partly due to increase of responsibility of the preparation to acetylcholine.
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